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Furthermore, conducting risk–benefit evaluations of omega-3 PUFA administration is crucial, aimed at identifying patient groups for whom omega-3 PUFA therapy would present an optimal risk–benefit balance (97)

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We constrained our review to five general areas of research in which measurement or manipulations of the glutamatergic system in groups of schizophrenia patients have been implemented: neuro-imaging (PET and 1 H-MRS), CSF and peripheral blood, post-mortem, genetics, and clinical trials